The science behind why cannabis-infused edibles make you feel high

Introduction to Cannabis-Infused Edibles

Cannabis-infused edibles have gained popularity in recent years due to their discreet and convenient nature. They provide an alternative method of consumption for those who prefer not to smoke or vaporize cannabis. However, many people wonder about the science behind why these edibles make you feel high. In this blog post, we will explore the chemistry and biology of cannabis-infused edibles and how they interact with our bodies to produce the desired effects.

Understanding THC and CBD

To understand the science behind cannabis-infused edibles, it is essential to know about the two primary cannabinoids found in cannabis: THC (tetrahydrocannabinol) and CBD (cannabidiol). THC is the psychoactive component responsible for the "high" feeling, while CBD is non-psychoactive and has been studied for its potential health benefits.

Decarboxylation: Activating the Cannabinoids

Before cannabis can be infused into edibles, it must undergo a process called decarboxylation. This process involves heating the raw cannabis plant material to convert the inactive acidic cannabinoids (THCA and CBDA) into their active forms (THC and CBD). Decarboxylation typically occurs when cannabis is smoked or vaporized, but it must be done separately for edibles to ensure the cannabinoids are bioavailable and effective.

How Edibles Are Metabolized in the Body

The way cannabis-infused edibles are metabolized in the body plays a significant role in why they make you feel high. When you consume an edible, the cannabinoids are absorbed through the gastrointestinal tract and then processed by the liver. This process is different from smoking or vaporizing cannabis, where the cannabinoids are absorbed directly into the bloodstream through the lungs.

First-Pass Metabolism and 11-Hydroxy-THC

During the liver's metabolism of THC, it is converted into a more potent compound called 11-hydroxy-THC. This compound is known to be more psychoactive than THC itself, which contributes to the heightened effects experienced with edibles. This process, known as first-pass metabolism, is unique to edibles and does not occur when cannabis is smoked or vaporized.

Why Edibles Have a Delayed Onset and Longer Duration

One of the most notable differences between edibles and other forms of cannabis consumption is the delayed onset and longer duration of effects. This is due to the way the body processes and absorbs the cannabinoids in edibles.

Delayed Onset

When you consume an edible, it can take anywhere from 30 minutes to 2 hours for the effects to be felt. This is because the cannabinoids must first pass through the digestive system and be metabolized by the liver before entering the bloodstream. This process takes time and can be influenced by factors such as the individual's metabolism, the presence of food in the stomach, and the specific type of edible consumed.

Longer Duration

The effects of cannabis-infused edibles also tend to last longer than those experienced with smoking or vaporizing. This is because the cannabinoids are released more slowly into the bloodstream as they are processed by the digestive system and liver. The duration of effects can range from 4 to 8 hours, depending on the individual and the dose of cannabinoids consumed.

Conclusion

The science behind why cannabis-infused edibles make you feel high is rooted in the unique way our bodies process and metabolize these products. The decarboxylation process activates the cannabinoids, while first-pass metabolism in the liver creates the more potent 11-hydroxy-THC. The delayed onset and longer duration of effects are a result of the cannabinoids' journey through the digestive system and liver before entering the bloodstream. Understanding this science can help individuals make informed decisions about their cannabis consumption and better anticipate the effects of cannabis-infused edibles.